Alloreactivity-Based Medical Conditions

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Alloreactivity-Based Medical Conditions

1 Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Medical Center, Washington, DC 20010, USA 2Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, MO 66160, USA 3Department of Pediatrics, University of Washington, Seattle Children’s Hospital, Seattle, WA 98109, USA 4Department of Physiology and Immunology, University of Rijeka, 5...

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Predicting Alloreactivity in Transplantation

Human leukocyte Antigen (HLA) mismatching leads to severe complications after solid-organ transplantation and hematopoietic stem-cell transplantation. The alloreactive responses underlying the posttransplantation complications include both direct recognition of allogeneic HLA by HLA-specific alloantibodies and T cells and indirect T-cell recognition. However, the immunogenicity of HLA mismatche...

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Underlying medical conditions.

More than half of maternal deaths in the UK are due to pre-existing medical conditions, and medical emergencies often mimic acute obstetric conditions. An acute flare of systemic lupus erythaematosus, a thyroid storm or a phaeochromocytoma have many of the signs and symptoms of imminent eclampsia. Similarly, severe postpartum haemorrhage can result in diagnostic difficulties of medical conditio...

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Direct alloreactivity is more susceptible to regulation by natural regulatory T cells than indirect alloreactivity.

The contribution of natural CD4(+)CD25(+) regulatory T cells (nTregs) in controlling graft rejection and the mechanism used remain controversial. Using the duality of the 2.102 TCR Ag recognition, we were able to study, for the first time to our knowledge, the involvement of nTregs in the two pathways of allorecognition in a murine adoptive transfer model in which TCR-transgenic nTregs were or ...

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Medical conditions affecting sports participation.

Children and adolescents with medical conditions present special issues with respect to participation in athletic activities. The pediatrician can play an important role in determining whether a child with a health condition should participate in certain sports by assessing the child's health status, suggesting appropriate equipment or modifications of sports to decrease the risk of injury, and...

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ژورنال

عنوان ژورنال: Clinical and Developmental Immunology

سال: 2013

ISSN: 1740-2522,1740-2530

DOI: 10.1155/2013/567084